Why the study?
How the sarcomeric complex is continuously turned-over in long-living cardiomyocytes was unclear under the prevailing model of sarcomere maintenance.
The study establishes a 'unidirectional replacement' model for cardiac sarcomere turnover, disproving the prevailing 'protein pool' model.
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Challenges protein pool model in animal sarcomeres; leaves open human translation and therapeutic relevance.
Douvdevany et al. (2023) studied this question.
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