Population
Adult cardiac myocytes in vitro
Design
Preclinical
Authors
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Protein-specific thin filament turnover in adult myocytes leaves open whether similar dynamics influence human cardiomyopathy progression or therapy.
The study demonstrates that myofilament protein replacement in adult cardiac myocytes is protein-specific, with TnI exchanging along the entire thin filament and Tm exchanging preferentially at the pointed end.
Michele et al. (1999) studied this question.
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