Key result
The association of nebulin in mature myofibrils renders tropomyosin less dynamic in skeletal muscle compared to cardiac muscle, where nebulin is expressed in minimal quantities.
Population
Cross-striated myocytes from vertebrates, including quail skeletal myotubes, embryonic chick cardiomyocytes…
Design
Review
Authors
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Distinguishes tropomyosin regulation by muscle type; leaves open whether dynamics influence cardiac function or disease.
This review highlights that nebulin likely stabilizes tropomyosin in mature skeletal muscle myofibrils, explaining the higher dynamics of tropomyosin in cardiac muscle which lacks significant nebulin.
Dube DK Wang J (2012) conducted a review in Myofibrillogenesis and muscle dynamics. Nebulin was evaluated. The association of nebulin in mature myofibrils renders tropomyosin less dynamic in skeletal muscle compared to cardiac muscle, where nebulin is expressed in minimal quantities.
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