Left ventricular hypertrophy and geometry in a population sample of elderly males
Population
584 males aged 70 in Uppsala, Sweden, including healthy subjects, subjects with hypertension, and subjects…
Design
Cross-sectional
Authors
Discussion
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Implication
May aid hypertensive heart disease characterization; leaves open causal links and therapeutic targets.
Key Points
- To examine the distribution of left ventricular geometric adaptations and their relationship to systolic and diastolic heart function in a general population of elderly men.
- Evaluated left ventricular geometric patterns (normal, concentric remodeling, concentric hypertrophy, eccentric hypertrophy) using echocardiography and Doppler ultrasound in 584 males aged 70 in Uppsala, Sweden.
- Assessed cardiac hemodynamics, systolic function, and diastolic filling across geometric groups while accounting for hypertension, coronary heart disease, and diabetes mellitus.
- Left ventricular hypertrophy was detected in 16% of healthy participants, 46% of hypertensive subjects (31% eccentric, 15% concentric; P < 0.001 vs. healthy), and was significantly elevated in normotensive subjects with coronary heart disease (P < 0.05).
- Both concentric and eccentric hypertrophy were associated with increased total peripheral resistance, higher blood pressure, and left atrial enlargement (P < 0.01 to 0.05), whereas Doppler cardiac index showed no significant differences among groups.
- Diastolic filling abnormalities differed by geometry, marked by prolonged isovolumic relaxation time in eccentric hypertrophy (P < 0.01) and increased atrial-dependent filling in concentric hypertrophy (P < 0.05).
Structured PICO
P
Population
584 males aged 70 in Uppsala, Sweden, including healthy subjects (n=167), subjects with hypertension (n=115), and subjects with coronary heart disease without hypertension (n=32).
O
Outcome
Relationships between left ventricular geometric shape (normal, concentric remodelling, concentric hypertrophy and eccentric hypertrophy) and left ventricular systolic and diastolic functionsurrogate
Cite This Study
Andrén et al. (1996) studied this question.