What does this research mean for the field?

Functional ACE2 is constitutively co-expressed with ACE as an ectoenzyme in human cardiac myofibroblasts, but not in vascular smooth muscle or endothelial cells, and undergoes inducible ectodomain shedding. Novelty: ClaimNovelty.NOVEL_FINDING. Consensus alignment: ConsensusAlignment.NEUTRAL.

January 26, 2008Experimental PhysiologyOpen Access

Functional angiotensin‐converting enzyme 2 is expressed in human cardiac myofibroblasts

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Population

Human cardiac myofibroblasts, vascular smooth muscle cells, vascular endothelium, and paraffin sections of…

Design

Preclinical

Authors

JGJodie L. GuyUniversity of Leeds DLD LambertMRC Centre for Regenerative Medicine ATAnthony J. TurnerUniversity of Leeds

Discussion

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Implication

Hypothesis-generating for ACE2 in cardiac fibrosis models; does not support changes in clinical practice.

Structured PICO

Population

Human cardiac myofibroblasts, vascular smooth muscle cells, vascular endothelium, and paraffin sections of atrial appendage tissue

Intervention

Phorbol-12-myristate-13-acetate (PMA) and other pathophysiological stimuli

Outcome

Expression and shedding of ACE2surrogate

This study demonstrates the functional co-expression of ACE and ACE2 in human cardiac myofibroblasts, providing a model to study their opposing roles in myocardial remodeling.

Cite This Study

Guy et al. (2008) studied this question.

synapsesocial.com/papers/6a1bd994d54006be995f1acc https://doi.org/10.1113/expphysiol.2007.040139

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Functional angiotensin‐converting enzyme 2 is expressed in human cardiac myofibroblasts

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Functional angiotensin‐converting enzyme 2 is expressed in human cardiac myofibroblasts

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider