Population
Cultured cardiac fibroblasts from 5-day-old Sprague-Dawley rat hearts exposed to acute hypoxia
Design
Preclinical
Authors
Loading...
May attenuate post-ischemic fibroblast activation; hypothesis-generating and requires in vivo validation before clinical consideration.
ACE2 overexpression in cardiac fibroblasts attenuates hypoxia-induced collagen and TGFbeta production, suggesting a potential therapeutic target to prevent adverse cardiac remodeling following acute ischemia.
Grobe et al. (2007) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: