T-Cell and NK-Cell Infiltration into Solid Tumors: A Key Limiting Factor for Efficacious Cancer Immunotherapy
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Implication
Review uncovers immunosuppressive barriers to lymphocyte trafficking in solid tumors, suggesting combination immunotherapies can restore antitumor responses.
Key Points
- To examine the immunosuppressive mechanisms that solid tumors use to hinder lymphocyte trafficking and evaluate therapeutic strategies to overcome these barriers.
- Reviewed cellular and molecular pathways that disrupt antigen presentation, T-cell and natural killer cell activation, and immune cell homing.
- Evaluated the role of tumor vasculature, soluble factors, myeloid-derived suppressor cells, and regulatory T cells in mediating immune evasion.
- Assessed emerging combination immunotherapy approaches designed to restore lymphocyte infiltration into tumors.
- Tumors impair sustained antitumor immunity by physically and biochemically restricting immune cell homing via abnormal vasculature and immunosuppressive cellular networks.
- Combination immunotherapies show promise in neutralizing suppressive mediators and enhancing lymphocyte recruitment into the tumor microenvironment.
Cite This Study
Melero et al. (2014) studied this question.