Why the study?
Does antihypertensive drug class affect medication adherence in clinical settings?
Population
Patients prescribed antihypertensive medications in clinical settings (17 studies)
Comparison
Antihypertensive drug classes vs Other antihypertensive drug classes
Design
Meta-analysis
Authors
Discussion
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Member takes
Implication
ARBs may be prioritized to improve adherence in hypertension; confirms class-specific differences for treatment selection and trials.
Structured PICO
Does antihypertensive drug class affect medication adherence in clinical settings?
P
Population
Patients prescribed antihypertensive medications in clinical settings (17 studies)
I
Intervention
Antihypertensive drug classes (angiotensin II receptor blockers, angiotensin-converting enzyme inhibitors, calcium channel blockers, diuretics, beta-blockers)
C
Comparator
Other antihypertensive drug classes
O
Outcome
Adherence to antihypertensives measured using medication refill data (reported as hazard ratios)
Adherence to antihypertensive medications varies significantly by drug class, with highest adherence to ARBs and ACE inhibitors and lowest to diuretics and beta-blockers, though overall adherence remains suboptimal.
Limitations
- Publication bias affected the significance of differences between ARBs and ACE inhibitors, and between diuretics and beta-blockers
Cite This Study
Kronish et al. (2011) studied this question.