Why the study?
Detailed information on regional atrial electrical properties in small animal models of heart disease and how they contribute to reentrant arrhythmia remains limited.
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Population
Isolated intact rat atria
Design
Experimental validation study
New rat bi-atrial platform enables regional atrial mapping in disease models; hypothesis-generating and leaves open clinical translation.
Despite wide-ranging optical mapping studies, detailed information on regional atrial electrical properties in small animal models of heart disease and how these contribute to reentrant arrhythmia remains limited. We have developed a novel experimental platform that enables both to be achieved in a geometrically intact isolated rat bi-atrial preparation.
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Ramlugun et al. (2021) studied this question.
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