Why the study?
Does oxprenolol cause less depression of left ventricular function compared to propranolol in patients undergoing cardiac catheterization?
Does oxprenolol cause less depression of left ventricular function compared to propranolol in patients undergoing cardiac catheterization?
Oxprenolol causes less depression of left ventricular function than propranolol while effectively reducing angina frequency.
Answers are grounded in this paper and cite their sources.
May favor oxprenolol when LV function is a concern; leaves open effects on clinical outcomes in angina.
Fourteen patients were studied during routine cardiac catheterization and had left ventricular function curves constructed before and after beta-adrenergic blockade. Seven patients received “Inderal” (propranolol) and seven “Trasicor” (oxprenolol). “Trasicor” resulted in less depression of left ventricular function. A limited double-blind study confirmed that “Trasicor” is capable of reducing the frequency of attacks of angina pectoris.
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Pitt et al. (1970) studied this question.
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