Why the study?
Little is known about how progressive primary hypokalemic periodic paralysis myopathy is, requiring natural history data and biomarkers for disease monitoring and trials.
Does quantitative muscle MRI detect disease progression in patients with hypokalemic periodic paralysis?
Population
Patients with primary hypokalemic periodic paralysis including asymptomatic carriers, periodic paralysis, and permanent weakness
Design
Prospective follow-up study
Follow-up
Median 20 months (range 12-25)
Authors
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Supports quantitative muscle MRI for detecting subclinical progression in hypokalemic periodic paralysis; hypothesis-generating and requires prospective validation before clinical adoption.
Does quantitative muscle MRI detect disease progression in patients with hypokalemic periodic paralysis?
Quantitative muscle MRI can detect subclinical disease progression in hypokalemic periodic paralysis over a median 20-month follow-up, whereas muscle strength testing does not.
Holm‐Yildiz et al. (2024) studied this question.
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