A Study of Pulmonary Function Tests in a Patients With Type 2 Diabetes Mellitus and Their Association With Glycaemic Control and Duration of Diabetes at Tertiary Care Hospital

Background- The pulmonary and other late complications of diabetes share a similar microangiopathy mechanism. Since, they share common mechanisms there may be associations between lung function and markers of microangiopathy. Therefore, we aimed to determine the association of pulmonary function with diabetes and the correlation of pulmonary function abnormalities with microvascular complications. Methods- This was a cross sectional comparative study carried out in a tertiary care teaching hospital in Jaipur,Rajasthan, India. Eligible participants included 100 adults below 60 years of age with T2DM attending the outpatient clinics or admitted to the wards during the study period, and an equal number of non-diabetic adults matched for age and gender who served as the comparative controls. Results- The present study clearly showed a highly statistically significant p value when the lung function tests (FVC, FEV1, and PEFR) were compared between type 2 diabetics and age, sex, BMI matched controls. The duration of DM and PFT correlation was found stastically significant and HbA1c and PFT correlation was found stastically Insignificant. Conclusion- Chronic hyperglycemia in diabetes may lead to diabetes associated systemic inflammation which results in airway and lung damage. Diabetes was more common in the sixth decade of life with slight male preponderance. The most common PFT derangement pattern in diabetic subjects is a restrictive pattern and having a significantly longer duration of a diabetic. The short-term indicators of glycemic controls were not significantly associated with a restrictive pattern of PFT. Keywords: Diabetes, Pulmonary function test, HbA1c, Duration of diabetes.