What does this research mean for the field?

Lower baseline ventilatory function independently predicts the long-term development of insulin resistance, suggesting that insulin resistance may mediate the established link between impaired lung function and coronary heart disease. Novelty: ClaimNovelty.NOVEL_FINDING. Consensus alignment: ConsensusAlignment.NEUTRAL.

September 1, 1998European Respiratory JournalOpen Access

Baseline ventilatory function predicts the development of higher levels of fasting insulin and fasting insulin resistance index: the Normative Aging Study

View Full Paper

Ask AI

Bookmark

Why the study?

Does baseline ventilatory function predict the development of insulin resistance in nondiabetic men?

Population

1050 nondiabetic male subjects in the Normative Aging Study

Design

Cohort

Follow-up

mean 20.9 yrs

Authors

RLRoss LazarusRoyal Australian College of General Practitioners DSDavid SparrowBroad Institute SWST WeissBrigham and Women's Hospital

Discussion

Member takes

Implication

Supports hypothesis that lower FVC predicts insulin resistance; hypothesis-generating for CHD mechanisms, needs prospective confirmation.

Structured PICO

Does baseline ventilatory function predict the development of insulin resistance in nondiabetic men?

Population

1050 nondiabetic male subjects in the Normative Aging Study

Intervention

Baseline ventilatory function (Forced vital capacity [FVC], forced expiratory volume in one second [FEV1], and maximal mid-expiratory flow rate [MMEF])

Outcome

Development of relative insulin resistance (defined as being in the top quintile of fasting insulin or fasting insulin resistance index [FIRI] levels at follow-up)surrogate

Impaired baseline ventilatory function predicts the long-term development of insulin resistance, suggesting a potential mechanism for the known association between reduced lung function and increased risk of coronary heart disease.

Cite This Study

Lazarus et al. (1998) studied this question.

synapsesocial.com/papers/6a1be3c9bc71fb1015a90ee9 https://doi.org/10.1183/09031936.98.12030641

View Full Paper

Ask AI

Bookmark

Baseline ventilatory function predicts the development of higher levels of fasting insulin and fasting insulin resistance index: the Normative Aging Study

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Baseline ventilatory function predicts the development of higher levels of fasting insulin and fasting insulin resistance index: the Normative Aging Study

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider