Why the study?
Does hypovolemia induced by incremental lower-body negative pressure reveal altered cardiovascular responsiveness in patients with HFpEF?
Does hypovolemia induced by incremental lower-body negative pressure reveal altered cardiovascular responsiveness in patients with HFpEF?
Patients with HFpEF exhibit impaired cardiopulmonary baroreflex function and altered autonomic cardiovascular regulation, which may be an important aspect of its pathophysiology.
May warrant hypovolemia caution in HFpEF; hypothesis-generating for baroreflex impairment in pathophysiology.
Data from the current study demonstrate diminished cardiovascular responsiveness during hypovolemia induced by incremental lower-body negative pressure in patients with heart failure with preserved ejection fraction (HFpEF). These diminished responses imply impaired cardiopulmonary baroreflex function and altered autonomic cardiovascular regulation which may represent an important aspect of HFpEF pathophysiology.
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Alpenglow et al. (2024) studied this question.
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