Impaired functional sympatholysis contributes to reduced exercising muscle blood flow in patients with HFpEF, providing insight into the pathophysiology of exercise intolerance in this population.
May limit exercise capacity in HFpEF; hypothesis-generating and requires prospective validation before clinical consideration.
Data from the current study suggest that functional sympatholysis, or the ability to adequately attenuate sympathetic nervous system (SNS)-mediated vasoconstriction during exercise, is impaired in patients with heart failure with preserved ejection fraction (HFpEF). These observations extend the current understanding of HFpEF pathophysiology by implicating inadequate functional sympatholysis as an important contributor to reduced exercising muscle blood flow in this patient group.
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Alpenglow et al. (2023) studied this question.
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