Key result
Peripheral abnormalities, including impaired skeletal muscle and microvascular function, contribute significantly to exercise intolerance in patients with heart failure with preserved ejection fraction.
This review highlights that exercise intolerance in HFpEF is driven significantly by peripheral mechanisms, which can be effectively targeted by physical training.
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Supports exercise training to target peripheral limitations in HFpEF; leaves open optimal regimens and confirmatory trials.
Upadhya et al. (2015) conducted a review in Heart failure with preserved ejection fraction (HFpEF). Peripheral abnormalities, including impaired skeletal muscle and microvascular function, contribute significantly to exercise intolerance in patients with heart failure with preserved ejection fraction.
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