Key result
Multi-organ cardiac and vascular changes drive potentially remediable exercise intolerance in HFpEF.
Why the study?
HFpEF accounts for over 50% of heart failure cases, but the complex multi-organ involvement requires an integrative approach to understand the cardiac and non-cardiac contributions to exercise intolerance.
This review emphasizes the multi-organ pathophysiology of exercise intolerance in HFpEF, highlighting peripheral vascular dysfunction as a potential therapeutic target.
Supports vascular-targeted interventions for HFpEF exercise intolerance; extends multi-organ framework but leaves open prospective trials.
Heart failure with preserved ejection fraction (HFpEF) accounts for over 50% of all heart failure cases nationwide and continues to rise in its prevalence. The complex, multi-organ involvement of the HFpEF clinical syndrome requires clinicians and investigators to adopt an integrative approach that considers the contribution of both cardiac and non-cardiac function to HFpEF pathophysiology. Thus, this symposium review outlines the key points from presentations covering the contributions of disease-related changes in cardiac function, arterial stiffness, peripheral vascular function, and oxygen delivery and utilization to exercise tolerance in patients with HFpEF. While many aspects of HFpEF pathophysiology remain poorly understood, there is accumulating evidence for a decline in vascular health in this patient group that may be remediable through pharmacological and lifestyle interventions and could improve outcomes and clinical status in this ever-growing patient population.
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Bunsawat et al. (2023) conducted a review in Heart failure with preserved ejection fraction (HFpEF). This symposium review highlights that exercise intolerance in HFpEF is driven by multi-organ changes, including cardiac function and vascular health, which may be remediable through interventions.
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