Key result
Exercise is a promising therapy to reverse metabolic derangements and improve exercise capacity in patients with heart failure with preserved ejection fraction.
Why the study?
Does exercise therapy improve exercise intolerance and metabolic derangements in patients with heart failure with preserved ejection fraction?
Does exercise therapy improve exercise intolerance and metabolic derangements in patients with heart failure with preserved ejection fraction?
This review outlines the pathophysiological mechanisms of exercise intolerance in HFpEF and provides a strong rationale for supervised exercise as a therapeutic strategy to improve myocardial bioenergetics and clinical outcomes.
Supports rationale for supervised exercise in HFpEF; leaves open need for large outcome RCTs.
More than 50% of Americans with heart failure have preserved ejection fraction (HFpEF). Exercise intolerance is a hallmark of HFpEF, but the pathophysiology is not well understood. Diverse etiologies and incomplete mechanistic understanding have resulted in ineffective management strategies to improve the outcomes of HFpEF. Traditional therapies that have been beneficial in the treatment of heart failure with reduced ejection fraction (HFrEF), neurohormonal blockade in particular, have not been effective in treating HFpEF. In this review, we address underlying mechanisms of HFpEF and present the rationale supporting exercise as a component of comprehensive management.
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Gupte et al. (2016) conducted a review in Heart failure with preserved ejection fraction (HFpEF). Exercise was evaluated. Exercise is a promising therapy to reverse metabolic derangements and improve exercise capacity in patients with heart failure with preserved ejection fraction.
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