What does this research mean for the field?

Stretch activation is a direct mechanical influence on muscle contraction that is functionally significant in insect flight and mammalian heart muscles, with the myosin filament likely acting as the mechanical sensor. Novelty: ClaimNovelty.SYNTHESIS. Consensus alignment: ConsensusAlignment.NEUTRAL.

May 5, 1978Proceedings of the Royal Society of London. Series B, Biological sciences

The Croonian Lecture, 1977 - Stretch activation of muscle: function and mechanism

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Population

insect fibrillar flight muscle, mammalian heart muscle, and vertebrate skeletal muscle models

Design

Review

Authors

JPJohn PringleUnited States Geological Survey

Discussion

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Implication

May support stretch activation in length-dependent cardiac tension; leaves open its contribution to Starling's Law relative to other mechanisms.

Structured PICO

Population

insect fibrillar flight muscle, mammalian heart muscle, and vertebrate skeletal muscle models

Intervention

stretch activation (changes of length)

Outcome

delayed change of active tension and actomyosin ATPase activity

Stretch activation is a key mechanical regulator of muscle tension and ATPase activity, with significant functional implications for mammalian heart muscle and Starling's Law.

Cite This Study

John Pringle (1978) studied this question.

synapsesocial.com/papers/6a1be653ea84844e355f261f https://doi.org/10.1098/rspb.1978.0035

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Implication

May support stretch activation in length-dependent cardiac tension; leaves open its contribution to Starling's Law relative to other mechanisms.

The Croonian Lecture, 1977 - Stretch activation of muscle: function and mechanism

Discussion

Member takes

Implication

Structured PICO

Cite This Study

The Croonian Lecture, 1977 - Stretch activation of muscle: function and mechanism

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider