December 9, 2010Proceedings of the National Academy of SciencesOpen Access

X-ray diffraction evidence for myosin-troponin connections and tropomyosin movement during stretch activation of insect flight muscle

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Population

Lethocerus muscles (insect flight muscle)

Design

Preclinical

Authors

RERobert J. EdwardsBeiersdorf (Germany)TIThomas C. IrvingHeart Failure / Cardiomyopathy BBBruce A.J. BaumannFlorida State University

Discussion

Member takes

Implication

Does not inform clinical practice; leaves open troponin bridge role in mammalian cardiac stretch activation.

Structured PICO

Population

Lethocerus muscles (insect flight muscle)

Intervention

Sinusoidal stretch activation

Outcome

Changes in X-ray reflections arising from myosin heads, actin filaments, troponin, and tropomyosinsurrogate

Troponin bridges appear to mechanically move tropomyosin to enable myosin-actin binding during stretch activation in insect flight muscle, suggesting a potential mechanism for stretch activation in mammalian cardiac muscle.

Cite This Study

Edwards et al. (2010) studied this question.

synapsesocial.com/papers/6a75747ef2cd31a1fadc12fd https://doi.org/10.1073/pnas.1014599107

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X-ray diffraction evidence for myosin-troponin connections and tropomyosin movement during stretch activation of insect flight muscle

Discussion

Member takes

Implication

Structured PICO

Cite This Study

X-ray diffraction evidence for myosin-troponin connections and tropomyosin movement during stretch activation of insect flight muscle

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider