What does this research mean for the field?

Visceral adipose tissue in morbidly obese patients is bioenergetically more active, has higher relative oxidative phosphorylation activity, and is more sensitive to mitochondrial substrate supply than subcutaneous adipose tissue. Novelty: ClaimNovelty.NOVEL_FINDING. Consensus alignment: ConsensusAlignment.NEUTRAL.

April 27, 2010The Journal of PhysiologyOpen Access

Mitochondrial respiration in subcutaneous and visceral adipose tissue from patients with morbid obesity

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Population

20 obese patients undergoing bariatric surgery

Design

Cross-sectional

Authors

RKRegitze KraunsøeUniversity of Copenhagen RBRobert BoushelUniversity of British Columbia CHChristina HansenMalmö University

Discussion

Member takes

Implication

Does not support clinical targeting of adipose mitochondria; leaves open links to cardiometabolic risk in obesity.

Structured PICO

Population

20 obese patients undergoing bariatric surgery

Comparator

Comparison between abdominal subcutaneous and intra-abdominal visceral (omentum majus) adipose tissue

Outcome

Mitochondrial respiration (oxygen flux) and mitochondrial densitysurrogate

Visceral adipose tissue is bioenergetically more active and more sensitive to mitochondrial substrate supply than subcutaneous fat in morbidly obese patients.

Cite This Study

Kraunsøe et al. (2010) studied this question.

synapsesocial.com/papers/6a1be6f76f692abb725ef655 https://doi.org/10.1113/jphysiol.2009.184754

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Mitochondrial respiration in subcutaneous and visceral adipose tissue from patients with morbid obesity

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Mitochondrial respiration in subcutaneous and visceral adipose tissue from patients with morbid obesity

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider