Key result
Visceral and thigh muscle fat linked to reduced maximal oxidative phosphorylation independent of BMI.
Why the study?
The association of ectopic adipose tissue with skeletal muscle mitochondrial bioenergetics in older adults had not been adequately examined.
Is regional ectopic adipose tissue associated with skeletal muscle mitochondrial bioenergetics in older adults independent of BMI and physical activity?
Population
829 older adults ≥70 years
Comparison
Regional adipose tissue distribution and thigh muscle fat infiltration assessed by MRI
Design
Cross-sectional study
Authors
Loading...
Visceral and muscle fat infiltration linked to lower muscle oxidative phosphorylation in older adults; leaves open whether reducing ectopic fat improves bioenergetics.
Cross-Sectional (n=829)
Yes
Is regional ectopic adipose tissue associated with skeletal muscle mitochondrial bioenergetics in older adults independent of BMI and physical activity?
Effect estimate: Std. β = -0.16
p-value: p=<0.05
Skeletal muscle fat infiltration and abdominal visceral adipose tissue are inversely associated with skeletal muscle mitochondrial bioenergetics in older adults independent of BMI, though in vivo associations are attenuated by physical activity.
Brennan et al. (2023) conducted a cross-sectional in Aging-related changes in body composition and skeletal muscle bioenergetics (n=829). Ectopic adipose tissue (visceral AT and thigh muscle fat infiltration) vs. Lower levels of ectopic adipose tissue was evaluated on Carbohydrate-supported maximal oxidative phosphorylation (OXPHOS) (Std. β = -0.16, p=<0.05). Visceral adipose tissue and thigh muscle fat infiltration were negatively associated with carbohydrate-supported maximal oxidative phosphorylation independent of BMI and physical activity (Std. β = -0.16 and -0.11, respectively).
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: