Key result
Adipose tissue distribution predicted insulin action in a sex-specific manner, with superficial subcutaneous fat explaining 29% of the variance in glucose disposal in women and 9% in men.
Cross-Sectional (n=57)
p-value: p=0.02
The distribution of subcutaneous adipose tissue predicts peripheral insulin action differently in men and women, highlighting sex-specific metabolic risks in obesity.
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Sex-specific fat distribution may refine insulin resistance phenotyping; hypothesis-generating and should not yet alter clinical practice.
Koška et al. (2008) conducted a cross-sectional in Obesity (n=57). Adipose tissue distribution (subcutaneous and intraabdominal fat) was evaluated on Peripheral (insulin-mediated glucose disposal) and hepatic (suppression of endogenous glucose production) insulin action (p=0.02). Adipose tissue distribution predicted insulin action in a sex-specific manner, with superficial subcutaneous fat explaining 29% of the variance in glucose disposal in women and 9% in men.
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