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July 1, 1995Journal of Clinical InvestigationOpen Access

Relationships of generalized and regional adiposity to insulin sensitivity in men.

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Key result

Subcutaneous truncal fat, measured by the sum of truncal skinfold thickness, showed the strongest inverse correlation (r = -0.72) with insulin sensitivity in healthy middle-aged men.

Population

39 healthy middle-aged men with a wide range of adiposity

Design

Cross-sectional

Authors

NANicola AbateTexas Medical CenterAGAnurag GargSynopsys (United States)RPRonald M. PeshockCardiac Imaging

Discussion

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Implication

Truncal subcutaneous fat may mark insulin resistance risk in men; hypothesis-generating and needs prospective validation before practice change.

Study Design

Type

Cross-Sectional (n=39)

Multicenter

No

Structured PICO

P
Population
39 healthy middle-aged men with a wide range of adiposity
O
Outcome
Insulin sensitivity measured by glucose disposal rate (Rd) and residual hepatic glucose output (rHGO) using hyperinsulinemic, euglycemic clamp techniquesurrogate

Main Result

Effect estimate: r = -0.72

p-value: p=<0.0001

Subcutaneous truncal fat plays a major role in obesity-related insulin resistance in men, whereas intraperitoneal and retroperitoneal fat have a lesser role.

Limitations

  • Did not study women, who may have greater variability in body fat distribution.
  • Did not identify lean men with selective intraperitoneal obesity.
  • Small sample size (n=39).

Cite This Study

Abate et al. (1995) conducted a cross-sectional in Healthy men with varying degrees of adiposity (n=39). Regional and generalized adiposity was evaluated on Correlation between glucose disposal rate (Rd) and sum of truncal skinfold thickness (r = -0.72, p=<0.0001). Subcutaneous truncal fat, measured by the sum of truncal skinfold thickness, showed the strongest inverse correlation (r = -0.72) with insulin sensitivity in healthy middle-aged men.

synapsesocial.com/papers/6a158b4b814bf8ec9a4ebde2https://doi.org/10.1172/jci118083
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Also Consider

Synapse has enriched 4 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1THE CHEMICAL COMPOSITION OF ADIPOSE TISSUE OF MAN AND MICE1962 · 213 citations
  2. 2Coated Charcoal Immunoassay of Insulin1965 · 2,995 citations
  3. 3Biochemical Determination of Training Effects Using Insulin Clamp Technique1984 · 67 citations
  4. 4Stimulation of Insulin Secretion by Long-Chain Free Fatty Acids. A DIRECT PANCREATIC EFFECT1973 · 165 citations