Key Points
- To determine the relationship among insulin-mediated glucose disposal, total and regional adiposity, and biological sex in Black individuals with non-insulin-dependent diabetes mellitus.
- Evaluated 32 Black men and 20 Black women with non-insulin-dependent diabetes mellitus (N=52; BMI 26.3 ± 2.3 and 27.2 ± 2.6 kg/m², respectively).
- Quantified total, subcutaneous, and visceral adipose tissue volume as well as skeletal muscle volume using 22 computed axial tomography scans.
- Measured insulin-mediated glucose disposal using the hyperinsulinemic euglycemic clamp technique.
- Women had approximately 80% more total fat (31.8 ± 8.3 vs. 18.6 ± 6.1 L) and subcutaneous fat (28.5 ± 7.3 vs. 14.7 ± 4.6 L) than men, whereas visceral fat volume was comparable (2.96 ± 1.22 vs. 3.49 ± 1.65 L).
- An inverse nonlinear relationship emerged between glucose disposal and visceral fat independent of sex (overall r = -0.58, P < 0.0001; men r = -0.60, women r = -0.59), with no significant differences in slope or intercept.
- Visceral adipose tissue accounted for 34% of the variance in insulin-mediated glucose disposal, whereas total fat, subcutaneous fat, and sex did not account for significant variance.
Structured PICO
PPopulation52 black subjects (32 men, 20 women) with non-insulin-dependent diabetes mellitus (NIDDM)
OOutcomeRelationship between insulin-mediated glucose disposal and visceral fat volumesurrogate
Visceral fat volume is inversely related to insulin-mediated glucose disposal in black patients with NIDDM, independent of sex.