Key result
Increased visceral adipose tissue in obese premenopausal women was associated with decreased sensitivity to insulin's antilipolytic effect in subcutaneous abdominal and gluteal adipocytes.
Population
Obese black and white premenopausal nondiabetic women matched for visceral adipose tissue, total adiposity…
Comparison
In vitro exposure to insulin or adenosine… vs Subjects with lowest VAT area; gluteal adipocytes
Design
Preclinical
Authors
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May link visceral obesity to systemic lipolysis via subcutaneous adipocytes; leaves open causal mechanisms and therapeutic targets.
Cross-Sectional
Insulin resistance in subcutaneous abdominal and gluteal adipocytes may contribute to increased systemic lipolysis in viscerally obese women.
Johnson et al. (2001) conducted a cross-sectional in Visceral obesity. Increased visceral adipose tissue (VAT) vs. Lowest VAT area was evaluated on Sensitivity to insulin's antilipolytic effect in subcutaneous abdominal and gluteal adipocytes. Increased visceral adipose tissue in obese premenopausal women was associated with decreased sensitivity to insulin's antilipolytic effect in subcutaneous abdominal and gluteal adipocytes.
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