Why the study?
Does the effect of insulin on regional adipose tissue lipolysis and lactate levels differ among upper-body obese, lower-body obese, and lean women?
Population
Upper-body overweight/obese (UBO), lower-body overweight/obese (LBO), and lean women
Comparison
2-h hyperinsulinemic euglycemic clamp vs Lean women and lower-body overweight/obese women
Design
Cross-sectional
Follow-up
2 hours
Authors
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Suggests regional insulin resistance in upper-body obesity; hypothesis-generating and should not yet change practice.
Does the effect of insulin on regional adipose tissue lipolysis and lactate levels differ among upper-body obese, lower-body obese, and lean women?
Upper-body obese women demonstrate metabolic inflexibility regarding insulin's antilipolytic and lactate-increasing effects in abdominal adipose tissue, reflecting regional insulin resistance.
Nellemann et al. (2011) studied this question.
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