Why the study?
Does insulin stimulation affect local tissue lactate production differently in healthy nonobese versus insulin-resistant obese women?
Population
22 women (11 healthy nonobese and 11 insulin-resistant obese)
Comparison
Hyperinsulinemic euglycemic clamp vs Healthy nonobese controls and postabsorptive state
Design
Cross-sectional
Authors
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Impaired lactate release in obese insulin-resistant women should not yet change practice; hypothesis-generating for tissue-specific defects.
Does insulin stimulation affect local tissue lactate production differently in healthy nonobese versus insulin-resistant obese women?
Insulin-resistant obese women exhibit impaired insulin-stimulated lactate release and local blood flow regulation in both adipose tissue and skeletal muscle.
Qvisth et al. (2006) studied this question.
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