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August 18, 2021MMWR Morbidity and Mortality Weekly ReportOpen Access

Effectiveness of Pfizer-BioNTech and Moderna Vaccines in Preventing SARS-CoV-2 Infection Among Nursing Home Residents Before and During Widespread Circulation of the SARS-CoV-2 B.1.617.2 (Delta) Variant — National Healthcare Safety Network, March 1–August 1, 2021

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SNSrinivas NanduriCenters for Disease Control and Prevention TPTamara PilishviliCenters for Disease Control and Prevention GDGordana DeradoCenters for Disease Control and Prevention

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Surveillance study reports declining mRNA vaccine effectiveness against SARS-CoV-2 infection among nursing home residents during Delta variant circulation, indicating the potential need for...

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To assess the effectiveness of Pfizer-BioNTech and Moderna mRNA vaccines in preventing SARS-CoV-2 infection among nursing home residents before and during the emergence of the Delta variant.
Analyzed weekly facility reports submitted to the National Healthcare Safety Network across pre-Delta (March 1–May 9, 2021; 17,407 reports from 3,862 facilities), intermediate (May 10–June 20, 2021; 33,160 reports from 11,581 facilities), and Delta periods (June 21–August 1, 2021; 85,593 reports from 14,917 facilities).
Calculated adjusted vaccine effectiveness against any confirmed SARS-CoV-2 infection for Pfizer-BioNTech and Moderna mRNA vaccines.
Adjusted vaccine effectiveness against infection decreased from 74.7% (95% CI, 70.0%–78.8%) in the pre-Delta period to 67.5% (95% CI, 60.1%–73.5%) in the intermediate period, and fell to 53.1% (95% CI, 49.1%–56.7%) during Delta variant predominance.
Vaccine effectiveness estimates were comparable between the Pfizer-BioNTech and Moderna mRNA vaccines across all analyzed periods.

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Nanduri et al. (2021) studied this question.

synapsesocial.com/papers/6a1be8964ebd09f3dfa932ad https://doi.org/10.15585/mmwr.mm7034e3

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Surveillance study reports declining mRNA vaccine effectiveness against SARS-CoV-2 infection among nursing home residents during Delta variant circulation, indicating the potential need for...

Effectiveness of Pfizer-BioNTech and Moderna Vaccines in Preventing SARS-CoV-2 Infection Among Nursing Home Residents Before and During Widespread Circulation of the SARS-CoV-2 B.1.617.2 (Delta) Variant — National Healthcare Safety Network, March 1–August 1, 2021

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Cite This Study

Effectiveness of Pfizer-BioNTech and Moderna Vaccines in Preventing SARS-CoV-2 Infection Among Nursing Home Residents Before and During Widespread Circulation of the SARS-CoV-2 B.1.617.2 (Delta) Variant — National Healthcare Safety Network, March 1–August 1, 2021

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