What question did this study set out to answer?

To determine the effectiveness of COVID-19 mRNA vaccines against COVID-19–associated hospitalization among US veterans, including during the emergence of the SARS-CoV-2 Delta variant.

September 10, 2021MMWR Morbidity and Mortality Weekly ReportOpen Access

Effectiveness of COVID-19 mRNA Vaccines Against COVID-19–Associated Hospitalization — Five Veterans Affairs Medical Centers, United States, February 1–August 6, 2021

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Authors

KBKristina L. BajemaOregon Health & Science University RDRebecca M. DahlFederal Reserve Bank of Atlanta MPMila M. PrillCenters for Disease Control and Prevention

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Implication

Observational study reveals high mRNA vaccine effectiveness against hospitalization in older veterans, highlighting durable protection against severe disease across variant waves.

Key Points

To determine the effectiveness of COVID-19 mRNA vaccines against COVID-19–associated hospitalization among US veterans, including during the emergence of the SARS-CoV-2 Delta variant.
Evaluated 1,175 adults aged ≥18 years hospitalized across five Veterans Affairs Medical Centers in the United States between February 1 and August 6, 2021.
Assessed a population characterized by high risk: 93.0% male, median age 68 years, 48.9% non-Hispanic Black, and 44.4% with a Charlson comorbidity index score ≥3.
Overall adjusted vaccine effectiveness against COVID-19–associated hospitalization was 86.8% (95% CI = 80.4%–91.1%).
Vaccine protection remained stable before (84.1%) and during (89.3%) SARS-CoV-2 Delta variant predominance.
Adjusted vaccine effectiveness was 79.8% (95% CI = 67.7%–87.4%) in adults aged ≥65 years compared with 95.1% (95% CI = 89.1%–97.8%) in those aged 18–64 years.

Cite This Study

Bajema et al. (2021) studied this question.

synapsesocial.com/papers/6a97b03e761fafb16923a2e0 https://doi.org/10.15585/mmwr.mm7037e3

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Implication

Observational study reveals high mRNA vaccine effectiveness against hospitalization in older veterans, highlighting durable protection against severe disease across variant waves.

Effectiveness of COVID-19 mRNA Vaccines Against COVID-19–Associated Hospitalization — Five Veterans Affairs Medical Centers, United States, February 1–August 6, 2021

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Cite This Study

Effectiveness of COVID-19 mRNA Vaccines Against COVID-19–Associated Hospitalization — Five Veterans Affairs Medical Centers, United States, February 1–August 6, 2021

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