What does this research mean for the field?

Overexpression of glutathione peroxidase (GSHPx) inhibits left ventricular remodeling and heart failure after myocardial infarction by reducing oxidative stress, myocyte hypertrophy, apoptosis, and interstitial fibrosis. Novelty: ClaimNovelty.NOVEL_FINDING. Consensus alignment: ConsensusAlignment.NEUTRAL.

January 27, 2004CirculationOpen Access

Overexpression of Glutathione Peroxidase Prevents Left Ventricular Remodeling and Failure After Myocardial Infarction in Mice

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Why the study?

Does overexpression of glutathione peroxidase prevent left ventricular remodeling and failure after myocardial infarction in mice?

Population

12- to 16-week-old male mice with myocardial infarction induced by left coronary artery ligation

Comparison

Overexpression of glutathione peroxidase via… vs Nontransgenic wild-type littermates with…

Design

Preclinical

Follow-up

4 weeks

Authors

TSTetsuya Shiomikeiyu Hospital HTHiroyuki TsutsuiHeart Failure & Transplant HMHidenori MatsusakaMatsuyama Red Cross Hospital

Discussion

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Implication

Hypothesis-generating for antioxidant modulation post-MI; leaves open clinical translation beyond this murine model.

Structured PICO

Does overexpression of glutathione peroxidase prevent left ventricular remodeling and failure after myocardial infarction in mice?

Population

12- to 16-week-old male mice with myocardial infarction induced by left coronary artery ligation

Intervention

Overexpression of glutathione peroxidase (GSHPx) via transgenic mouse model

Comparator

Nontransgenic wild-type littermates with myocardial infarction

Outcome

Left ventricular remodeling and failure (including survival rate, LV cavity dilatation, LV dysfunction, and LV end-diastolic pressure) at 4 weekssurrogate

Overexpression of glutathione peroxidase in mice attenuates left ventricular remodeling and improves survival after myocardial infarction, highlighting the therapeutic potential of targeting oxidative stress in heart failure.

Cite This Study

Shiomi et al. (2004) studied this question.

synapsesocial.com/papers/6a1be8fbfc87fd06169cea77 https://doi.org/10.1161/01.cir.0000109701.77059.e9

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Overexpression of Glutathione Peroxidase Prevents Left Ventricular Remodeling and Failure After Myocardial Infarction in Mice

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Overexpression of Glutathione Peroxidase Prevents Left Ventricular Remodeling and Failure After Myocardial Infarction in Mice

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

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