Why the study?
Does overexpression of the GSHPx gene attenuate myocardial remodeling and preserve diastolic function in a diabetic mouse model?
Population
Male mice with diabetes mellitus induced by streptozotocin injection (160 mg/kg ip)
Comparison
Overexpression of glutathione peroxidase gene vs Nontransgenic wildtype littermates with diabetes…
Design
Preclinical
Follow-up
8 weeks
Authors
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Antioxidant overexpression may mitigate diabetic diastolic dysfunction; leaves open translation to human cardiomyopathy.
Does overexpression of the GSHPx gene attenuate myocardial remodeling and preserve diastolic function in a diabetic mouse model?
Overexpression of the antioxidant enzyme GSHPx ameliorates left ventricular remodeling and diastolic dysfunction in a diabetic mouse model, highlighting the role of oxidative stress in diabetic cardiomyopathy.
Matsushima et al. (2006) studied this question.
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