What does this research mean for the field?

Electrophysiological mechanisms, including ion fluxes, calcium release, and membrane potential changes, regulate the secretion of essential lubricants and cytokines from synovial fibroblasts, offering new pathophysiological insights into rheumatoid arthritis. Novelty: ClaimNovelty.SYNTHESIS. Consensus alignment: ConsensusAlignment.NEUTRAL.

April 15, 2016The Journal of PhysiologyOpen Access

Cellular electrophysiological principles that modulate secretion from synovial fibroblasts

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Population

Synovial fibroblasts from animal models, human tissues, and isolated cells in culture

Design

Review

Authors

RCRobert B. ClarkUniversity of Calgary TSTannin A. SchmidtUConn Health FSFrank B. SachseC3J Therapeutics (United States)

Discussion

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Implication

New RA pathophysiological insights from synovial electrophysiology; hypothesis-generating and should not yet change practice.

Structured PICO

Population

Synovial fibroblasts from animal models, human tissues, and isolated cells in culture

Understanding the electrophysiological mechanisms of synovial fibroblasts offers new pathophysiological insights into rheumatoid arthritis.

Cite This Study

Clark et al. (2016) studied this question.

synapsesocial.com/papers/6a1be908ea84844e355f2ac2 https://doi.org/10.1113/jp270209

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Cellular electrophysiological principles that modulate secretion from synovial fibroblasts

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Cellular electrophysiological principles that modulate secretion from synovial fibroblasts

Discussion

Member takes

Implication

Structured PICO

Cite This Study

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Also Consider