May 1, 1997Current Opinion in Rheumatology
Cellular pathways of joint destruction
Key result
Recent research explores cellular pathways in rheumatoid synovial fibroblasts to inhibit cartilage destruction.
Why the study?
Evaluation of cellular pathways of rheumatoid synovial fibroblasts is critical to understanding the molecular mechanisms in rheumatoid arthritis pathogenesis.
Population
Rheumatoid synovial fibroblasts in rheumatoid arthritis
Design
Review of recent laboratory studies and gene therapy trials
Authors
Discussion
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Member takes
Implication
Hypothesis-generating for RA fibroblast-targeted therapies; extends mechanistic insights but leaves open clinical translation.
Structured PICO
P
Population
Rheumatoid arthritis (focus on rheumatoid synovial fibroblasts)
This review summarizes recent advances in understanding the cellular mechanisms of joint destruction in rheumatoid arthritis, including early gene therapy trials.
Cite This Study
ller-Ladner et al. (1997) conducted a review in Rheumatoid arthritis. Cellular pathways of rheumatoid synovial fibroblasts was evaluated. Recent research on cellular pathways of rheumatoid synovial fibroblasts has focused on adhesion, intracellular signaling, gene transcription, and novel approaches to inhibiting cartilage destruction.