What does this research mean for the field?

Inwardly rectifying K+ (Kir) currents determine the resting membrane potential in ventricular fibroblasts and myofibroblasts, and altering this potential modulates their proliferation and contractile functions. Novelty: ClaimNovelty.NOVEL_FINDING. Consensus alignment: ConsensusAlignment.NEUTRAL.

January 15, 2005AJP Heart and Circulatory PhysiologyOpen Access

K+ currents regulate the resting membrane potential, proliferation, and contractile responses in ventricular fibroblasts and myofibroblasts

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Population

Ventricular fibroblasts and myofibroblasts

Comparison

Modulation of external K+ concentration and Ba2+… vs Control external K+ concentration (5.4 mM)

Design

Preclinical

Authors

LCLisa ChiltonLoyola University Medical Center SOSusumu OhyaNagoya City University DFDarren H. FreedCardiac Surgery

Discussion

Member takes

Implication

Altered extracellular K+ modulates myofibroblast proliferation and contractility in vitro; hypothesis-generating for fibrosis but should not change practice.

Structured PICO

Population

Ventricular fibroblasts and myofibroblasts

Intervention

Modulation of external K+ concentration (1.5 mM or 20 mM) and Ba2+ block (100-300 muM)

Comparator

Control external K+ concentration (5.4 mM)

Outcome

Resting membrane potential, proliferation (myofibroblast number), and contractile responses (collagen I gel contraction)surrogate

In ventricular fibroblasts and myofibroblasts, Kir currents determine resting membrane potential, and altering external K+ concentrations modulates cellular proliferation and contractility.

Cite This Study

Chilton et al. (2005) studied this question.

synapsesocial.com/papers/6a1be90cea84844e355f2acf https://doi.org/10.1152/ajpheart.01220.2004

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Implication

Altered extracellular K+ modulates myofibroblast proliferation and contractility in vitro; hypothesis-generating for fibrosis but should not change practice.

K+ currents regulate the resting membrane potential, proliferation, and contractile responses in ventricular fibroblasts and myofibroblasts

Discussion

Member takes

Implication

Structured PICO

Cite This Study

K+ currents regulate the resting membrane potential, proliferation, and contractile responses in ventricular fibroblasts and myofibroblasts

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider