Population
Myocytes isolated from subendocardial layers of left ventricular septum from patients with nonfailing hearts…
Design
Preclinical
Authors
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IK1 kinetic shifts may promote excitability and arrhythmias in hypertrophy; animal findings leave open clinical relevance and K+-targeted interventions.
In human ventricular hypertrophy, alterations in IK1 current kinetics dependent on extracellular K+ and potentially intracellular polyamines might favor enhanced excitability and underlie ventricular arrhythmias.
Bailly et al. (1998) studied this question.
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