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This research investigates the characteristics of K currents in feline ventricular myocytes under normal and hypertrophied conditions.

Outward currents in normal and hypertrophied feline ventricular myocytes

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IK1/IK properties in feline RVH myocytes warrant no clinical change; leaves open ionic remodeling mechanisms in human hypertrophy.

This research investigates the characteristics of K currents in feline ventricular myocytes under normal and hypertrophied conditions.
Isolated feline myocytes from right ventricle were studied.
Comparative analysis of inward rectifier K current (IK1) and delayed rectifier K current (IK) was performed.
Electrical properties including activation and deactivation kinetics were measured.
IK1 increased in magnitude in hypertrophied myocytes, while IK decreased.
IK demonstrated slower activation and faster deactivation in hypertrophied myocytes.
IK showed enhanced rectification at positive potentials in hypertrophy, which may lead to prolonged action potential duration.

Kleiman et al. (1989) studied this question.

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