Why the study?
Does β-adrenergic stimulation induce Ca waves by increasing SR Ca content or decreasing the threshold in the RyR2 R4496C mouse model of CPVT?
Population
Ventricular myocytes from the RyR2 R4496C(+/-) mouse model of CPVT and wild-type (WT) controls
Comparison
β-adrenergic stimulation with isoproterenol vs Wild-type (WT) controls
Design
Preclinical
Authors
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Refines Ca wave mechanism in R4496C CPVT model; leaves open translation to human therapy.
Does β-adrenergic stimulation induce Ca waves by increasing SR Ca content or decreasing the threshold in the RyR2 R4496C mouse model of CPVT?
In the RyR2 R4496C mouse model of CPVT, β-adrenergic stimulation induces arrhythmogenic Ca waves by increasing SR Ca content rather than by lowering the threshold for waves.
Kashimura et al. (2010) studied this question.
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