December 12, 2006Proteins Structure Function and Bioinformatics
The role of phosphorylation on the structure and dynamics of phospholamban: A model from molecular simulations
Population
Molecular dynamics simulations of unmodified and phosphorylated phospholamban immersed in a phospholipid…
Comparison
Phosphorylation of Ser16 vs Unmodified PLB
Design
Preclinical
Authors
Discussion
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Member takes
Implication
May inform SERCA-targeted heart failure therapies; leaves open translation from simulations to in vivo cardiac models.
Structured PICO
P
Population
Molecular dynamics simulations of unmodified and phosphorylated phospholamban (PLB) immersed in a phospholipid membrane
I
Intervention
Phosphorylation of Ser16
C
Comparator
Unmodified PLB
O
Outcome
Structure and dynamics of PLB
Molecular dynamics simulations suggest that phosphorylation of phospholamban alters its cytoplasmic domain structure and interactions, relieving its inhibition of the SERCA pump.
Cite This Study
Pantano et al. (2006) studied this question.