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January 1, 2015International Heart JournalOpen Access

The ratio of myocardial necrotic area to AAR significantly decreased in all tirofiban subgroups, and the apoptotic index was significantly decreased at a tirofiban concentration of ≥ 0.4 ug/kg/minute.

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Why the study?

Does tirofiban reduce cardiac reperfusion injury and myocyte apoptosis in a rat model of myocardial infarction?

Population

Rats subjected to 120 minutes of coronary ligation and 180 minutes of reperfusion

Comparison

Tirofiban administered intravenously at various… vs Control group

Design

Preclinical

Follow-up

180 minutes

Authors

SCShih‐Tai ChangCCChang‐Min ChungCCChi‐Ming Chu

Discussion

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Overview

Tirofiban may reduce experimental reperfusion injury; hypothesis-generating in rat MI model only and should not change practice.

Structured PICO

Does tirofiban reduce cardiac reperfusion injury and myocyte apoptosis in a rat model of myocardial infarction?

P
Population
Rats subjected to 120 minutes of coronary ligation and 180 minutes of reperfusion
I
Intervention
Tirofiban administered intravenously at various concentrations from 30 minutes prior to coronary reperfusion to the end of reperfusion
C
Comparator
Control group (implied by division into 7 groups based on concentration)
O
Outcome
Ratio of myocardial necrotic area to area at risk (AAR)surrogate

Tirofiban significantly ameliorates cardiac reperfusion injury and myocyte apoptosis in a rat model of myocardial infarction.

Cite This Study

Chang et al. (2015) studied this question.

synapsesocial.com/papers/6a1bf0894ebd09f3dfa93b35https://doi.org/10.1536/ihj.14-322
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Tirofiban: an investigational plateletglycoprotein IIb/IIIa receptor antagonist1997 · 18 citations
  2. 2Tirofiban: A Critical Reappraisal of the Clinical use, Recent Developments and Future Perspectives2005 · 2 citations
  3. 3Inhibition of the Platelet Glycoprotein IIb/IIIa Receptor with Tirofiban in Unstable Angina and Non–Q-Wave Myocardial Infarction1998 · 1,330 citations
  4. 4Effect of Tirofiban Therapy on ST Segment Resolution and Clinical Outcomes in Patients with ST Segment Elevated Acute Myocardial Infarction Undergoing Primary Angioplasty2006 · 11 citations
  5. 5Effects of Glycoprotein IIb/IIIa Receptor Inhibition with Tirofiban on Minor Myocardial Damage in Angiographically Successful Percutaneous Coronary Angioplasty2004 · 11 citations