Why the study?
Does a GP IIb/IIIa receptor inhibitor preserve coronary flow reserve during progressive coronary arteriostenosis in a swine model compared to heparin, aspirin, or saline?
Population
28 pigs instrumented with an aortic catheter, hydraulic occluders, and flow probes on the left anterior…
Comparison
Glycoprotein IIb/IIIa receptor inhibitor vs Heparin, aspirin, or saline (control)
Design
Preclinical
Follow-up
Acute (minutes)
Authors
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GP IIb/IIIa inhibition may preserve coronary vasodilator response in stenosis; leaves open translation to human disease.
Does a GP IIb/IIIa receptor inhibitor preserve coronary flow reserve during progressive coronary arteriostenosis in a swine model compared to heparin, aspirin, or saline?
A platelet GP IIb/IIIa receptor inhibitor preserves the distal coronary vasodilatory response during progressive coronary arteriostenosis in a swine model.
Shen et al. (2000) studied this question.
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