Why the study?
Does the discontinuation of intravenous heparin alone increase the risk of reactivation of unstable angina compared to aspirin, both, or placebo in patients with unstable angina?
Population
n=403 patients with unstable angina who had completed six days of blinded therapy without refractory angina…
Comparison
Intravenous heparin alone vs Aspirin alone, both treatments, or neither
Design
RCT, randomized, double-blind, placebo-controlled
Follow-up
96 hours
Authors
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Discontinue IV heparin monotherapy cautiously in unstable angina; confirms aspirin co-therapy prevents early reactivation.
Does the discontinuation of intravenous heparin alone increase the risk of reactivation of unstable angina compared to aspirin, both, or placebo in patients with unstable angina?
Discontinuation of intravenous heparin alone in unstable angina can lead to early reactivation of the disease, which may be prevented by concomitant aspirin therapy.
Théroux et al. (1992) studied this question.
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