What does this research mean for the field?

Mengo, encephalomyocarditis (EMC), Columbia-SK, and M.M. viruses constitute a closely related group of viruses that are antigenically and pathogenically distinct from poliomyelitis, refuting the prior classification of Columbia-SK and M.M. as rodent-adapted poliomyelitis strains. Novelty: ClaimNovelty.CONTRADICTORY. Consensus alignment: ConsensusAlignment.CHALLENGES_CONSENSUS.

August 1, 1949The Journal of ImmunologyOpen Access

The Relationship of Mengo Encephalomyelitis, Encephalomyocarditis, Columbia-SK and M.M. Viruses

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Population

Small laboratory animals, monkeys, and human sera

Comparison

Mengo, encephalomyocarditis, Columbia-SK, and… vs Poliomyelitis virus strains

Design

Preclinical

Authors

GDG. W. A. DickGFZ Helmholtz Centre for Geosciences

Discussion

Member takes

Implication

May warrant dropping poliomyelitis designation for these strains; challenges prior mutant classification and leaves open distinct taxonomy.

Structured PICO

Population

Small laboratory animals, monkeys, and human sera (including 7 persons with '3-day fever' in Manila and 143 sera from Uganda)

Intervention

Mengo, encephalomyocarditis (EMC), Columbia-SK, and M.M. viruses

Comparator

Poliomyelitis virus strains (Lansing, Yale-SK, MEF-1)

Outcome

Serological relationship, cross-immunity, and pathogenicity

Columbia-SK, M.M., EMC, and Mengo viruses constitute a single group of closely related viruses distinct from poliomyelitis, suggesting the 'poliomyelitis' designation should be dropped for these strains.

Cite This Study

G. W. A. Dick (1949) studied this question.

synapsesocial.com/papers/6a1bf331d54006be995f48a5 https://doi.org/10.4049/jimmunol.62.4.375

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Implication

May warrant dropping poliomyelitis designation for these strains; challenges prior mutant classification and leaves open distinct taxonomy.