Key result
Aerosolized cardiovirus pathogenicity in mice varies widely by viral plaque size and circulating antibodies.
Why the study?
Differences in pathogenicity of encephalomyocarditis virus group strains or their infectious nucleic acids when delivered as aerosols in mice were not fully characterized.
Key points are not available for this paper at this time.
Population
Mice exposed to aerosols of different encephalomyocarditis virus group strains or Mengo RNA
Comparison
Different virus strains and infectious nucleic acids (intact virus vs RNA) with or without circulating antibodies
Design
Experimental aerosol exposure study in mice
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May inform aerosol viral models of myocarditis; leaves open human translation and clinical relevance.
Akers et al. (1968) studied this question. Aerosolized encephalomyocarditis viruses and Mengo RNA exhibited varying pathogenicity in mice that correlated with viral plaque size, intact versus RNA state, and circulating antibodies.
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