Key result
Mengo-2T virus induced diabetes and destroyed pancreatic beta cells in multiple inbred mouse strains, including those resistant to encephalomyocarditis virus-induced diabetes.
Population
Male inbred mice (SJL/J, C57BL/6J, CBA/J, CE/J, C3H/HeJ, and AKR/J), 5 to 6 weeks old
Comparison
Infection with Mengo-2T virus vs Infection with the D variant of…
Design
Preclinical
Follow-up
Up to 7 days
Authors
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Mengo-2T model extends EMCV findings to resistant strains; hypothesis-generating for viral diabetes mechanisms with no human implications yet.
This preclinical study demonstrates that a specific clone of Mengovirus (Mengo-2T) can infect pancreatic beta cells and induce diabetes across multiple mouse strains, including those resistant to EMC-D-induced diabetes.
Yoon et al. (1984) studied Virus-induced diabetes mellitus. Mengo-2T virus vs. EMC-D virus was evaluated on Development of abnormal glucose tolerance and pancreatic beta cell destruction. Mengo-2T virus induced diabetes and destroyed pancreatic beta cells in multiple inbred mouse strains, including those resistant to encephalomyocarditis virus-induced diabetes.
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