What does this research mean for the field?

Prior exposure to herpes simplex virus (HSV) or cytomegalovirus (CMV) does not increase the risk of future myocardial infarction or stroke in apparently healthy middle-aged men. Novelty: ClaimNovelty.CONTRADICTORY. Consensus alignment: ConsensusAlignment.CHALLENGES_CONSENSUS.

What question did this study set out to answer?

To investigate the relationship between herpes simplex virus and cytomegalovirus exposure and the risk of future myocardial infarction and stroke.

December 22, 1998CirculationOpen Access

Prospective Study of Herpes Simplex Virus, Cytomegalovirus, and the Risk of Future Myocardial Infarction and Stroke

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Why the study?

Does prior exposure to HSV or CMV increase the risk of future myocardial infarction and stroke in apparently healthy men?

Key Points

To investigate the relationship between herpes simplex virus and cytomegalovirus exposure and the risk of future myocardial infarction and stroke.
Nested case-control design involving 643 men who developed MI or stroke and 643 healthy controls matched by age and smoking status.
Assessment of IgG antibodies for HSV and CMV along with cardiovascular risk factor adjustments during 12-year follow-up.
Analysis of blood plasma concentration of C-reactive protein as a marker of inflammation.
Relative risk for future MI with HSV seropositivity was 0.94 (95% CI, 0.7 to 1.2).
Relative risk for future MI with CMV seropositivity was 0.72 (95% CI, 0.6 to 0.9).
No evidence of association found between antibody presence and C-reactive protein levels.

Structured PICO

Does prior exposure to HSV or CMV increase the risk of future myocardial infarction and stroke in apparently healthy men?

Population

1,286 apparently healthy middle-aged men (643 who developed a first MI or thromboembolic stroke and 643 age- and smoking-matched controls who remained free of reported vascular disease)

Intervention

Seropositivity for herpes simplex virus (HSV) or cytomegalovirus (CMV) IgG antibodies

Comparator

Seronegativity for HSV or CMV

Outcome

Future myocardial infarction (MI) and thromboembolic strokehard clinical

IgG antibodies directed against HSV or CMV do not appear to be a marker for increased atherothrombotic risk in apparently healthy middle-aged men.

Discussion

No takes yet. Share an insight, caveat, or question.

Implication

HSV/CMV seropositivity not linked to higher MI/stroke risk in healthy men; challenges prior hypotheses but leaves causality open.

Cite This Study

Ridker et al. (1998) studied this question.

synapsesocial.com/papers/6a1bf40cc97d63156a5f2336 https://doi.org/10.1161/01.cir.98.25.2796

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Prospective Study of Herpes Simplex Virus, Cytomegalovirus, and the Risk of Future Myocardial Infarction and Stroke

Key Points

Structured PICO

Discussion

Implication

Cite This Study

Prospective Study of Herpes Simplex Virus, Cytomegalovirus, and the Risk of Future Myocardial Infarction and Stroke

Key Points

Structured PICO

Discussion

Implication

Cite This Study

Also Consider

Also Consider