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Suggests mechanism for orthostatic intolerance across fitness levels; hypothesis-generating pending prospective validation.
Augmentation of left ventricular (LV) untwisting due to central hypovolemia is likely to be a compensatory mechanism for maintaining stroke volume, which is reduced by a decrease in cardiac filling during orthostatic stress. Orthostatic intolerance observed in both high and low fitness levels may be explained by the impaired response of LV untwisting due to central hypovolemia.
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Shibata et al. (2021) studied this question.
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