What does this research mean for the field?

In patients with aortic stenosis, long axis excursion is reduced even when fractional shortening and ejection fraction are normal, and it is significantly lower in symptomatic compared to asymptomatic severe cases. Novelty: ClaimNovelty.INCREMENTAL. Consensus alignment: ConsensusAlignment.NEUTRAL.

What question did this study set out to answer?

To assess long axis excursion across varying severities of aortic stenosis with preserved transverse systolic function and evaluate differences between symptomatic and asymptomatic severe cases.

July 1, 2001HeartOpen Access

Long axis excursion in aortic stenosis

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Why the study?

Does long axis excursion differ across grades of aortic stenosis and between symptomatic and asymptomatic severe aortic stenosis?

Population

102 subjects total: 78 patients with all grades of aortic stenosis and normal fractional shortening and…

Comparison

Echocardiographic assessment of long axis… vs Comparisons between different grades of aortic…

Design

Cohort

Authors

STScott TakedaMaidstone Hospital

Discussion

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Implication

May support symptom stratification in severe aortic stenosis; leaves open its prognostic utility and role in timing intervention.

Key Points

To assess long axis excursion across varying severities of aortic stenosis with preserved transverse systolic function and evaluate differences between symptomatic and asymptomatic severe cases.
Prospective comparative study conducted at a regional cardiothoracic centre in 78 patients with aortic stenosis and preserved systolic function, 10 age-matched healthy controls, and 14 patients with reduced fractional shortening (< 26%).
Echocardiography was used to measure aortic valve function, left ventricular mass index, and M-mode long axis excursion at the septal and lateral mitral annulus.
Long axis excursion differed significantly across groups at the septal (p < 0.0001) and lateral mitral annulus (p = 0.002) and was independently related to left ventricular mass index (p = 0.001) and aortic stenosis grade (p = 0.002).
Patients with symptomatic severe aortic stenosis had significantly lower lateral mitral annulus excursion (p = 0.04) and smaller effective orifice area (p = 0.02) than asymptomatic patients, despite similar ejection fraction, fractional shortening, and pressure gradients.

Structured PICO

Does long axis excursion differ across grades of aortic stenosis and between symptomatic and asymptomatic severe aortic stenosis?

Population

102 subjects total: 78 patients with all grades of aortic stenosis and normal fractional shortening and ejection fraction, 10 age-matched normal subjects, and 14 patients with aortic stenosis and fractional shortening < 26%.

Intervention

Echocardiographic assessment of long axis excursion using M mode at the septal and lateral sides of the mitral annulus

Comparator

Comparisons between different grades of aortic stenosis, normal subjects, patients with reduced fractional shortening, and symptomatic versus asymptomatic severe aortic stenosis

Outcome

Long axis excursion at the septal and lateral sides of the mitral annulussurrogate

Long axis excursion is reduced in aortic stenosis despite normal ejection fraction and is lower in symptomatic versus asymptomatic severe aortic stenosis, suggesting utility in predicting symptom onset.

Cite This Study

Scott Takeda (2001) studied this question.

synapsesocial.com/papers/6a1bf4ce01af05bf0da9049a https://doi.org/10.1136/heart.86.1.52

Topics

Echocardiography

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Long axis excursion in aortic stenosis

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Topics

Long axis excursion in aortic stenosis

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Also Consider

Topics

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