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April 1, 1985Circulation ResearchOpen Access

New studies of the excitatory sodium currents in heart muscle.

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Population

Cardiac single cells and purified Na+ channel proteins

Design

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Authors

HFHarry A. FozzardUniversity of VermontCraig T. JanuaryCraig T. JanuaryElectrophysiologyJMJ. C. MakielskiUniversity of Wisconsin–Madison

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Implication

Challenges Hodgkin-Huxley applicability to cardiac Na currents; leaves open heart-specific kinetic models for arrhythmia research.

Structured PICO

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Population
Cardiac single cells and purified Na+ channel proteins

Cardiac sodium channels exhibit unique kinetic behaviors and lower density compared to other excitable tissues, indicating that the traditional Hodgkin-Huxley model is inadequate for describing cardiac excitation.

Cite This Study

Fozzard et al. (1985) studied this question.

synapsesocial.com/papers/6a1bf8811567d2fc4d5f592dhttps://doi.org/10.1161/01.res.56.4.475
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Increase in intracellular sodium ion activity during stimulation in mammalian cardiac muscle.1982 · 256 citations
  2. 2Maximal upstroke velocity as an index of available sodium conductance. Comparison of maximal upstroke velocity and voltage clamp measurements of sodium current in rabbit Purkinje fibers.1984 · 152 citations
  3. 3Membrane current following activity in canine cardiac Purkinje fibers.1984 · 32 citations
  4. 4An improved vaseline gap voltage clamp for skeletal muscle fibers.1976 · 311 citations
  5. 5The surface area of sheep cardiac Purkinje fibres1972 · 184 citations