What does this research mean for the field?

Cl--HCO3- exchange plays no significant role in the recovery from intracellular acidification in cardiac Purkinje fibers. Novelty: ClaimNovelty.INCREMENTAL. Consensus alignment: ConsensusAlignment.NEUTRAL.

May 1, 1984AJP Cell Physiology

Analysis of Cl- -HCO3(-) exchange during recovery from intracellular acidosis in cardiac Purkinje strands

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Population

Isolated cardiac Purkinje strands

Comparison

Acidification produced by withdrawing 20 meq… vs Normal CO2-HCO3(-)-buffered superfusate

Design

Preclinical

Authors

BVBert VanheelGhent University Hospital AHA. de HemptinneVrije Universiteit Brussel ILI LeusenÉcole Normale Supérieure

Discussion

Member takes

Implication

Does not implicate Cl--HCO3 exchange in Purkinje pHi recovery; hypothesis-generating for human cardiac acid-base mechanisms.

Structured PICO

Population

Isolated cardiac Purkinje strands

Intervention

Acidification produced by withdrawing 20 meq NH+4 from the superfusate, tested in HCO3(-)-free, Cl-free solutions, and in the presence of SITS (a blocker of Cl--HCO3(-) exchange)

Comparator

Normal CO2-HCO3(-)-buffered superfusate

Outcome

Recovery of intracellular pH (pHi) from acidosissurrogate

In isolated cardiac Purkinje strands, recovery from intracellular acidosis does not significantly rely on Cl--HCO3(-) exchange.

Cite This Study

Vanheel et al. (1984) studied this question.

synapsesocial.com/papers/6a1bf8811567d2fc4d5f5930 https://doi.org/10.1152/ajpcell.1984.246.5.c391

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Bookmark

Analysis of Cl- -HCO3(-) exchange during recovery from intracellular acidosis in cardiac Purkinje strands

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Analysis of Cl- -HCO3(-) exchange during recovery from intracellular acidosis in cardiac Purkinje strands

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider